BIMAL PHARMA PVT. LTD.   www.bimalpha.com

PRODUCT : CHLORZOXAZONE  

1 NOMENCLATURE 
  • 5 - Chloro - 2 - Hydroxy Benzoxazole.
  • 2 - Hydroxy - 5 - Chlorobenzoxazole.
  • 5 - Chloro - 2 - benzoxazolinone
2 CAS NO.  95-25-0
3 EMPIRICAL FORMULA  C7 H4 CL N O2
4 MOL. WT. 169.58
5 STRUCTURAL FORMULA 
6 MELTING RANGE  189ºC - 194ºC
7 DESCRIPTION 
  • Light Yellowish / Whitish or Whitish Fine Crystalline Powder.
  • Odourless.
8 SOLUBILITY 
  • It is slightly soluble in water.
  • It is sparingly soluble in Alcohol; and in Isopropyl Alcohol (IPA), and also in Methanol.
  • It is soluble in solutions of Alkali Hydroxides and Ammonia.
9 IDENTIFICATION 

A) By I.R

B) By U.V

 
  • IR complies with Standard Spectrum of USP Chlorzoxazone R.S.
  • UV Absorption Spectrum of 1 in 50,000 complies with standard spectrum of USP Chlorzoxazone R.S. 
10 RESIDUE ON IGNITION  Not more than 0.15%
11

RELATED SUBSTANCE        

BY TLC         

(Chromatographic Purity )

2- Amino-4- Chloro Phenol : NMT 0.50%

P-Chloro Phenol               : NMT 0.25%

 

12 CHLORINE CONTENT  Between 20.6% and 21.2% 
13 HEAVY METALS  Not more than 0.002% (20 ppm)
14 LOSS ON DRYING  Not more than 0.5%
15

ORGANIC VOLTILE IMPURITIES

 

Chloroform 

Methylene Chloride 

1-4 dioxane 

Trichloroethylene 

 

 

  • Less than 60 mcg/gm

  • Less than 600 mcg/gm

  • Less than 380 mcg/gm

  • Less than 80 mcg/gm
16 ASSAY (ODB) Between 98% to 102%
17 PACKING  25 Kgs. Fibre Drums with double LDPE Liners.
18 THERAPEUTIC USE As a centrally acting skeletal muscle relaxant.